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Home Remedies:
There are as many home remedies for soothing the painful blisters and itching of poison oak, ivy and sumac as there are people who have experienced the discomfort. However, most home remedies only sooth the itching as long as the remedy is being administered. There are, some commercially available treatments that are more effective.

Over-the-Counter Drugs:
Anti-Itch creams available at any supermarket are effective at stopping the itch. Caladryl "clear lotion" works well for this purpose because it helps with the itching and also tends to dry out the rash and prevent blistering.

Doctor Prescribed:
In advanced cases of poison oak, ivy, or sumac, where the rash is on your face, on or near genitals, or if it covers most of your body, it is recommended that you see your physician. Your doctor may prescribe a prescription drug called prednisone. Prednisone is actually a mild steroid which is used to treat hundreds of different conditions to limit the bodies immune response. In the case of a poisonous rash from a plant, the drug keeps the bodies immune system from trying to "fight" the urushiol and cause the uncomfortable rash.